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Regulatory T cell differentiation: Cooperation saves the day – Adaptive Immunology Laboratory

Regulatory T cell differentiation: Cooperation saves the day

Year
2015
Type(s)
Author(s)
Adrian Liston, Susan M. Schlenner
Source
The EMBO Journal
Url
http://emboj.embopress.org/content/34/9/1145
BibTeX
BibTeX

MicroRNA are important regulators of CD4 T cell differentiation, altering the balance between the immunogenic and tolerogenic pathways. Studies in mice with microRNA-deficient T cells have revealed defects in differentiation into the regulatory T cell lineage; however, the individual microRNA responsible have remained elusive. A recent paper in The EMBO Journal uses a systematic screen to find a novel cooperative action between an inducible and a constitutive microRNA in aiding regulatory T cell induction.